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| Amaral,Gisele Ferreira; Dossa,Pietro Domingues; Viebig,Lígia Bocamino; Konno,Fabiana Toshie Camargo; Consoli,Amanda; Martins,Maria de Fátima Monteiro; Viani,Flávio Cesar; Bondan,Eduardo Fernandes. |
| ABSTRACT Pro-inflammatory cytokines and glial cells, especially microglial cells, have been implicated in persistent pain sensitization. Less is known about the role of astrocytes in pain regulation. This study aimed to observe the expression of the astrocytic biomarker glial fibrillary acidic protein (GFAP) and the serum levels of interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) after short-term administration of central pain relievers in rats not submitted to noxious stimuli. Male Wistar rats were divided into five groups, receiving for nine days- (1) amitriptyline (Amt-10 mg/kg/day, by gavage); (2) gabapentin (Gb-60 mg/kg/day, by gavage; (3) methadone (Me-4.5 mg/kg/day, intraperitoneal route [IP]); (4) morphine (Mo-10 mg/kg/day, IP);... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neuropathic pain/treatment; Astrocytes/pain regulation; Analgesics/tests/treatment; Cytokines; Glial Fibrillary Acidic Protein/study. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400623 |
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